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KMID : 0848120190440010020
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International Journal of Oral Biology
2019 Volume.44 No. 1 p.20 ~ p.26
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Porphyromonas gingivalis lipopolysaccharide stimulates vascular smooth muscle cell migration through signal transducer and activator of transcription 3-mediated matrix metalloproteinase-9 expression
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Kim Yeon
Park Joo-Yeon
Park Hyun-Joo
Kim Mi-Kyoung
Kim Yong-Il
Bae Soo-Kyung
Kim Hyung-Joon
Bae Moon-Kyoung
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Abstract
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Periodontal diseases have been associated with the development of cardiovascular diseases. Accumulating evidences have indicated that Porphyromonas gingivalis , a major periodontopathic pathogen, plays a critical role in the pathogenesis of atherosclerosis. In the present study, we demonstrated that P. gingivalis lipopolysaccharide (LPS) increases the mRNA and protein expression of matrix metalloproteinase-9 (MMP-9) in rat vascular smooth muscle cells. We showed that the MMP-9 expression induced by P. gingivalis LPS is mediated by the activation of signal transducer and activator of transcription 3 (STAT3) in vascular smooth muscle cells. Furthermore, the inhibition of STAT3 activity reduced P. gingivalis LPS-induced migration of vascular smooth muscle cells. Overall, our findings indicate that P. gingivalis LPS stimulates the migration of vascular smooth muscle cells via STAT3-mediated MMP-9 expression.
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KEYWORD
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Porphyromonas gingivalis, Vascular smooth muscle cells, Matrix metalloproteinase 9, STAT3 transcription factor
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